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Endocr Rev 40:10481079

But some women notice that their menstrual cycle feels slightly different during the first month of therapy

Further research on PDE-5 and PTX, to include large multi center double blind, randomized-control trials, are needed to determine their efficacy

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Both were placed on FDA Category 2 in September 2023, removed in September 2024 after withdrawn nominations, and reviewed by PCAC in late 2024 with FDA recommending against 503A Bulks inclusion