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58 Rofecoxib (Vioxx, Merck, Kenilworth, NJ, USA) and Valdecoxib (Bextra, Pfizer, New York, NY, USA) were withdrawn from the market for associated cardiovascular risks and other side effects

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Fortunately, conjugation generally moves the absorption maxima to longer wavelengths, as in the case of isoprene, so conjugation becomes the major structural feature identified by this technique

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