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Common adverse effects include: Gastrointestinal symptoms : Nausea, vomiting, diarrhoea, constipation, and abdominal pain are the most frequently reported side effects, typically occurring during dose escalation

Other side effects may include injection site reactions

Pharmacological studies demonstrate that blocking either GLP-1R or glucose-dependent insulinotropic polypeptide receptor (GIPR) partially reduces Tirzepatide-induced insulin secretion, but only simultaneous blockade of both receptors eliminates this effect 36

doi:10.1038/s41580-018-0094-y

Pfizer has not been a major player in the weight loss drug market to date

Gastroparesis symptoms include acid reflux and stomach pain