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Based on the evidence, a clinical guideline for autism [32] recommended melatonin 2 mg as an initial dose and increased up to 5 mg depending on the severity of sleep problems, as opposed to low dosages less than 1 mg used for chronobiotic effects

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Safety advice Do not use during pregnancy or breastfeeding unless your clinician specifically advises it

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Setting realistic expectations helps ensure satisfaction with treatment outcomes: Timeline for Results: Most men begin noticing improvements within 2-4 weeks, with more significant benefits developing over 2-3 months of consistent treatment