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[10] The first amylin analogue to reach the clinic, pramlintide, demonstrated that the pathway could be drugged, but native-style amylin analogues are short-acting and were used as multiple-daily injections, which limited their appeal for weight management

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Griendling KK, Ushio-Fukai M, Lassegue B, Alexander RW

[5] Eli Lilly

When you have an infection, injury, or anything that triggers inflammation, your body launches what's called an acute-phase response