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Mitochondrial Dysfunction in down Syndrome: Molecular Mechanisms and Therapeutic Targets
Gamma-H2AX, generated from the rapid phosphorylation of H2AX histone protein at the serine-139 position in early response to a broad range of DNA lesions, is a highly effective biomarker for DNA strand breaks and DNA oxidation and plays a central role in sensing and repairing DNA damage [52,53,54]
In another study involving the same mouse strain, McElwee and colleagues found that a diet containing soybean oil reduced the incidence of AA [30]
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