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Lilly argued the Cmax reduction was of limited clinical relevance because AUC drives contraceptive efficacy

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[8] Serious adverse effects are uncommon

Angiogenesis Studies: Angiogenic potential investigated through multiple assays: HUVEC tube formation (network complexity), endothelial migration (cells/field), aortic ring sprouting (sprout length/number), VEGF/VEGFR2 expression (qPCR, Western blot), CAM assay (vessel density)