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BRAFE600-associated senescence-like cell cycle arrest of human naevi

While its activity is often associated with disease progression through the promotion of ferroptosis and oxidative damage, it also holds potential as a therapeutic target, with selective inhibition of CHAC1 offering possible benefits in conditions where its overexpression drives pathology

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Tannins (TA) , which complex with iron without binding to endogenous iron-containing molecules, are also an effective measure for the treatment of diseases associated with iron overload (Phiwchai et al., 2018)

A question remains as to whether this therapy is effective in patients with existing HFpEF or if its primary benefit lies in impacting risk factors and associated cardiovascular diseases that contribute to the development of HFpEF