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The effect of the above-mentioned combinations on the mitochondrial membrane potential was confirmed when comparing values at a later time point (60 s), when the Rho123 fluorescent signal deflected from linearity to approach the equilibrium (Fig

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In the Phase 3 TRIUMPH-4 trial, retatrutide at 12 mg produced 28.7% body weight loss at 68 weeks vs 2.1% for placebo