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These two pathways cooperate in several ways: IFN-I generated by cGAS-STING heightens NLRP3 sensitivity, and NLRP3-dependent IL-1 upregulates cGAS via NF-KB, creating a positive-feedback loop
Medinos data shows these complaints are common enough that simple, repeatable measures usually resolve them without stopping therapy
Anderberg et al
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Without that signal, muscle is the first thing the body is willing to give up
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