Both cells and islets were stimulated with 100 nM exendin-4 or vehicle for 10 minutes and subsequently labelled with MitoTracker Red CMXRos (Thermo Fisher Scientific), washed 1 with PBS and imaged in phenol red free RPMI-1640 in a Leica Stellaris 8 inverted confocal microscope with 63/1.40 NA (islets) or 100/1.40 NA (cells) oil immersion objectives
Thus, the technical advances in understanding the distribution and functional roles of GLP-1R across peripheral and central systems continue to inform the development of more effective therapies targeting both metabolic and behavioral domains
Human data, however, remain inconclusive
Pompella, et al., Biochem
Its advisable not to plan important activities immediately after dosing, in case an erection occurs unexpectedly
Im just looking for options that feel true to me at this stage, knowing things can always change down the road