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The side effects are real annoying at best and debilitating at worst and can include nausea, diarrhea, cramps and abdominal pain, constipation, vomiting, gastroesophageal reflux, gastroenteritis, pancreatitis, gastroparesis, intestinal obstruction, gall bladder disease, headaches and potential risk for certain types of thyroid and endocrine cancers, among other adverse effects

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Tailored dosing and monitoring guidelines must be developed to mitigate risks while maximizing benefits

Thus, is it reasonable to proceed as usual, as the guidance states

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Months 1 to 12: Biweekly coaching and lifestyle curriculum Youll meet with your coach every other week to set goals and troubleshoot challenges