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NICE recommends: Consider SLNB for melanoma with a Breslow thickness of 0.8 mm to 1.0 mm with ulceration, lymphovascular invasion or a mitotic index of 2 or more Consider SLNB for melanoma with a Breslow thickness greater than 1.0 mm SLNB is typically performed after diagnostic excision, often at the time of wide local excision in suitable patients

To become an active antioxidant again, it needs to be reduced, and it uses the energy from the NAD+ pathway to do this

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Kurita M, et al