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Semaglutide is used in FDA-approved products for chronic weight management in certain adults with obesity or overweight, and in other products for type 2 diabetes management and certain cardiovascular risk reduction indications

The GIP receptor has additional effects on glucose metabolism, appetite signaling, and energy expenditure compared to GLP-1 alone

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Too little peptide and gene expression changes remain subtle

doi: 10.1016/0002-9378(95)90336-4 63 KandzijaNZhangWMotta-MejiaCMhlomiVMcGowan-DowneyJJamesTet al

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