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This is potentially dangerous and almost certainly counterproductive
The ago-allosteric small molecule compound 2 enhances binding of the agonist GLP-1 but does not affect binding of the antagonist exendin (9-39) and it cannot be inhibited by the peptide antagonist exendin (9-39), which is not surprising considering the intracellular binding site of compound 2 32,35,36
Decreased appetite is an expected pharmacological effect rather than an adverse event, though the degree of appetite suppression can be more pronounced than some patients anticipate
Pharmaceuticals 17:1109
When available, discuss with your healthcare provider to see if retatrutide is right for you
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