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292 Exercise is a key part of combatting metabolic changes that begin in perimenopause and lead to decreased fat burning, weight gain, muscle loss, and increased abdominal fat accumulation

Willpower was never the problem

In cases where the source of the bleed is unclear, but melena is present, an upper endoscopy is recommended, to try to ascertain the source of the bleed

While these medications offer significant metabolic benefits, the physiological alterations they can induce are not without potential concerns

"Anecdotally, people with food addiction who find GLP-1s helpful in this regard talk about how the medication turns down the volume of 'food noise' in the brain, by which they mean the constant thoughts and cravings for certain types of food," Lembke said

FASEB J (2019) 33:1425469