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10.1016/S0887-8994(97)00026-X Matsumoto J, Ogawa H, Maeyama R, Okudaira K, Shinka T, Kuhara T, Matsumoto I: Successful treatment by direct hemop-erfusion of coma possibly resulting from mitochondrial dysfunction in acute valproate intoxication

Some researchers also suggest glutathione can directly bind with the active site of tyrosinase (which contains copper), effectively inactivating the enzyme and further halting melanin synthesis

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