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Quick look at the key results According to clinical trial investigators, orforglipron: Led to significant weight reduction across all dosing groups Showed greater effects at the highest dose levels Helped lower blood sugar in people with diabetes Supported modest improvements in blood pressure Demonstrated mainly mild to moderate side effects The trial results suggest that the once-daily pill performs competitively with early GLP-1 injection studies

A 1993 paper describes an experiment in which rats were implanted with wound chamber models that were subsequently treated with either GHK-Cu or a saline placebo

Whether this is a practical strategy is questionable

The FDA approved it anyway, and 3 panel members resigned over the decision.One resigning panelist called it one of the worst approval decisions in the agency's history

Widgerow AD, Cohen SR, Fagien S

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