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How many subjects are involved

Yu ZY et al

For many, butyrate is used to improve symptoms of gas, bloating, and constipation which is particularly helpful when fighting SIBO (which thrives on slow gut motility)

It can also stimulate cortisol and prolactin

Efficacy endpoints were change from baseline in HbA 1c and body weight (and, for the separate PIONEER 8 subgroup analysis, change from baseline in insulin dose) at the planned end of treatment (weeks 26, 52 or 78, according to the trial)