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Although innovations such as vascularization, genome editing, omics-techniques, high-content imaging (HCI), machine-learning-based and automated systems are already a reality in organoids, protocols need to continue evolving to improve tissue communication, cell patterning signals, body axis simulation and spatial-temporal control of differentiation (Lokai et al., 2023)

Similar antioxidant mechanisms were observed in our ischemia-reperfusion (IR) injury model, where bromelain restored oxidative balance through reductions in TOS and OSI and by increasing TAS

Finally, we discuss promising therapeutic strategies targeting this -syn-ferroptosis axis, including -syn aggregation inhibitors, iron chelators, and glia-modulating agents, highlighting their potential as disease-modifying interventions

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