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The CD38 glycohydrolase and the NAD sink: implications for pathological conditions

10.1016/j.exer.2015.04.016 75 Medvidovic-GrubisicM.StambolijaV.KolencD.KatancicJ.MurselovicT.Plestina-BorjanI.et al (2017)

Key molecular mechanisms involve positive feedback loops: ischemia-triggered DAMPs activate P2X7 receptors in lipid rafts, increasing calcium influx

BTW, it's also a building block of a bunch of important and famous peptides, including copper-tripeptide-1, palmitoyl tripeptide-1 or palmitoyl hexapeptide-12

Gershon MD, Margolis KG

It was derived from a protective sequence found naturally within human gastric juice protein