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Without the DAC group, the peptide is short-acting it clears within a few hours and produces a sharp, brief GH pulse

Hu D, Zhang X, Gong S, Ma W, Cheng B, Yang J, Yan L, Li B, Qiu T, Wang X (2025) An injectable hydroxyapatite microsphere filler loaded with GHK-Cu tripeptide for anti-inflammatory and antioxidant

What the evidence suggests: dermatological observations have noted skin-brightening effects, particularly in hyperpigmentation, melasma, and post-inflammatory darkening

Some release of histamine is necessary

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The key to long-term success is using the treatment period to build lasting healthy habits that sustain your results after the injections end