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Combined SGLT2i and GLP-1RA therapy resulted in a significantly lower risk of all-cause death, non-fatal myocardial infarction, and non-fatal stroke at 12 months than SGLT2i monotherapy (HR, 1.77

Key points Regulated cell death through either apoptosis or necrosis contributes to parenchymal cell loss in acute and chronic kidney disease and may also modulate inflammation, fibrosis and the immune response

Tirzepatide's own dedicated cardiovascular outcomes trials (including NCT07619508 and NCT06980623) are still ongoing, so its heart-health data, while promising, is less mature than semaglutide's

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Activation of the FGF19 gene results in the protein being secreted into the enterohepatic circulation

10.1006/frne.2001.0224 38 HajnalA.ZharikovA.PolstonJ