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The first step is rate-limiting and subject to feedback inhibition by glutathione itself, holding intracellular concentrations in the low millimolar range, typically 1 to 8 mM (Griffith, Free Radical Biology and Medicine, 1999
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Iron regulatory proteins and the molecular control of mammalian iron metabolism
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Research indicates DSIP may promote delta-wave (slow-wave) sleep, modulate cortisol and ACTH levels, and exhibit stress-protective properties [3] [4]