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7 Computations were performed separately for each sex and both sexes together and, additionally, for obese individuals with a BMI 27 kg/m 2 (irrespective of SCORE2), those with a SCORE2-derived CVD risk 7.5% (irrespective of BMI) as well as for the overall study cohort (irrespective of both SCORE2 and BMI), and for the outcomes 5-year incidence of CVD or death from any cause, respectively

Cochain C, Channon KM, Silvestre JS

Data availability All data points shown in graphs, as well as the RNA-Seq differential fold change dataset, are available in the Supporting Data Values file

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Hyperbolic saturation receptor occupancy = [free drug] / ([free drug] + EC50)

Over the past two decades, several studies have indicated that neuroinflammation is a critical reason for the onset, deterioration, relapse, and maintenance of depression ( Figure 2 ) (Kopschina Feltes et al., 2017