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Unfortunately, edaravone can only be used in a small subset of early-stage ALS patients (grade 1 or 2 in the Japan ALS Severity Classification, scoring at least 2 points on all 12 items of ALSFRS-R

This multi-pathway activity resembles what we see with other biologic treatments in orthopedic surgery, where the therapeutic effect comes from coordinated biological response rather than a single drug-receptor interaction

Ann Transl Med (2021) 9:1670

Synthesis of (((ethane-1,2-diylbis(azanediyl))bis(carbonyl))bis(4,1-phenylene))diboronic acid(EBPBA) 4-Carboxyphenylboronic acid (3.65 g, 22.00 mmol), ethylenediamine dihydrochloride (1.33 g, 10.00 mmol), HATU (11.40 g, 30.00 mmol) and HOAT (4.08 g, 30.00 mmol) were dissolved in DMF (40 mL) under nitrogen atmosphere and ice bath conditions

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