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GLP-1 may spread into laminae IIIII from other, more densely innervated laminae by volume transmission through the neuropil

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We also examined the ability of the hydrogel-based long-acting TZP formulations to reduce average BG after each 6-week treatment regimen

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Ideally, quantification of secreted GLP-1 must be based on its concentration immediately at the site of its release in the intestine where it exerts a local effect to activate vagal sensory neurons within the intestinal wall so that vasovagal reflexes important to global metabolic homeostasis can be initiated 26,27

Avoid repeated freeze-thaw cycles as that degrades peptides