Ferroptosis A form of programmed cell death that is dependent on intracellular iron, characterized by the intracellular accumulation of lipid peroxides
Researchers also distinguish reduced glutathione (GSH) from the disulfide GSSG, since it is the GSSG/2GSH ratio, not total glutathione, that Schafer and Buettner (Free Radical Biology and Medicine, 2001) established as the quantitative index of the cellular redox environment
Taking its name from the Greek name "Karren" (meaning "pureness"), CARE:NEL advocates respect for Mother Nature by avoiding artificial ingredients and animal testing
Combining antiangiogenic agents, such as saikosaponin b2 which targets the VEGF/ERK/HIF-1 pathway, with immunotherapy enhances treatment efficacy
The first scaffold is a tertiary amine that acquires a positive charge in response to an acidic component in endosomes and lysosomes that promotes membrane destabilization and subsequent endosomal escape
10.2174/1381612824666180614082950 34 KlicekR.KolencD.SuranJ.DrmicD.BrcicL.AralicaG.et al (2013)