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Structural and biochemical analyses reveal the mechanism of glutathione S-transferase Pi 1 inhibition by the anti-cancer compound piperlongumine

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Through ATF4-mediated integrated stress responses, cancer cells acquire not only drug persistence, ferroptosis sensitivity, and also metastatic phenotype 45,46,47

By promoting the removal of heavy metals, toxins, and free radicals, it improves liver function and reduces the risk of liver-related issues, including fatty liver disease

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