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In cells incubated with [ 13 C 5 ]KIV, we observed increases in the concentrations of M4 isobutyrylcarnitine and M4 3HIB as the dose of BCATi increased, consistent with a shift toward higher use of the labeled substrate due to inhibition of reverse transamination (Supplemental Figure 2, B and C)

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Chronic inflammation reduces significantly

Role of mitochondrial dynamics in heart diseases