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Is reactive oxygen species production elevated

AMPK Activation Acts as a metabolic regulator: turns on AMPK, the master energy sensor controlling glucose and fatty-acid oxidation

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Rather, mutations affecting the dimerization interfaces of the G6PD protein and in proximity to the NADP + binding site may cause more detrimental effects compared to mutations of residues in other less conserved sites

Hence, we mutated all 4 K to arginine (R), which mimicked the deubiquitination of the protein

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