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Glutamate synthesis and degradation in differently located astrocytes was envisaged to present a possible problem in the suggested interacting pathways of glutamate production and oxidation with its exclusive use of aspartate aminotransferase (Figure 3B) rather than GDH (Hertz, 2011a)

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Deletion of both Gpx4 alleles in mice or pharmacologic GPX4 inhibition in cells induces a distinct regulated form of iron-dependent cell death termed ferroptosis 1

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As we age or face chronic stress, poor nutrition, or environmental toxins, our natural glutathione levels can become depleted