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Interestingly, the mitochondrial morphology changes triggered by exendin-4 in Control RNAi-treated cells were accompanied by a significant reduction in ERMCS length, which appeared already reduced under vehicle conditions, without further effect of exendin-4, following SPHKAP downregulation (Fig

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The associated G-proteins activated by ligand binding to GHS-R1a are of the G q/11 family