Triptolide is a diterpene epoxy compound extracted from Tripterygium wilfordii, which is a highly effective Nrf2 inhibitor
cognition and behavior) (the highest being the worst), Epworth Sleepiness Scale 25 (/24, the highest being the worst), PD sleep scale 26 (/150, the highest being the best), MOCA 27 (/30, the highest being the best), Neuropsychiatric Inventory-Clinician 28 (/798, the highest being the worst), Parkinson Anxiety Scale 29 (/48, the highest being the worst), Lille Apathy Rating Scale 30 (36 to +36, the highest being the worst) and the ECMP French scale of assessment of hyperdopaminergic and hypodopaminergic behaviors in PD (ref
(2023) 18:e202200583
Notably, the proportion stopping treatment because of side effects (7%) was barely above placebo (6%) closer than usual for this class
doi: 10.1186/1471-2458-9-88 21 YounossiZM
Note that in the majority of the participants, the weight loss obtained is well above 5% of the initial weight (the minimum associated with an improvement in health) and even exceeds 20% in many of them, in particular in the participants who received tirzepatide