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Understanding GLP-1 Basics GLP-1 stands for glucagon-like peptide-1

A recent study showed promising results for retatrutide in treating metabolic dysfunction-associated steatotic liver disease (MASLD), in terms of significant reduction in liver fat, with up to 82.4% decrease at 24 weeks with higher doses [58]

B6 mice fed with a normal fat diet (Normal Diet) or HFD (DIO) received the following treatment regimens: saline (Saline), scExe4 donor DNA-loaded LNP (Donor), or scExe4 donor DNA plus Cas9-coding DNA-loaded LNP (Donor+Cas9)

and Lindstedt, G

Alorfi, N

These findings indicate that continuous Exe4 secretion via genome editing does not substantially suppress endogenous GLP-1 secretion