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Evidence level is high based on confirmed Phase 3 data
Several enzymes involved in ATP production contain Fe-S clusters in the active site and are subject to similar inactivation by superoxide, including oxoglutarate dehydrogenase of the tricarboxylic acid cycle, as well as ETC complexes IIII
In summary, at first glance, these studies suggest antioxidant strategies are not effective in ALS, but this may reflect the specific unfavorable pharmacological properties of the antioxidants trialled so far
Management of type 2 diabetes: A handbook for general practice
Proper screening helps ensure the patient is a good candidate for liposuction and can recover well, minimizing the chances of problems during or after the procedure
