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They occur due to megaloblastic anemia resulting from impaired red blood cell formation

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doi:10.1001/jamadermatol.2013.1083

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In particular, VD analogs such as cholecalciferol, calcitriol, and paricalcitol demonstrated a significant improvement in renal function in two RCTs, possibly due to their ability to bypass the renal-dependent 1-alphahydroxylation process

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