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129 Upon activation of SIRT3, hepatocyte mitochondrial oxidative stress was reduced, and mitochondrial dysfunction was alleviated, which reduced hepatocyte apoptosis and alleviated hepatic fibrosis

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Statistics by two-sided unpaired t-tests compared to untreated empty vector transduced cells (g-i)

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Because of this and the fact that the body only needs a small amount of vitamin B12 each day, it can take up to a year or even longer for an inadequate vitamin B12 to manifest as an apparent deficiency