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GLP-1RAs, as an important class of drugs for the treatment of T2DM, shows significant advantages in blood glucose control, weight loss, cardiovascular protection and kidney benefit (Ussher and Drucker, 2023

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For instance: Chemotherapy Drugs: Glutathione might reduce the effectiveness of some chemotherapy drugs by protecting cells from oxidative damage, which is a key mechanism through which these drugs work

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In the Look AHEAD study, intensive lifestyle interventions leading to weight loss improved glycemic control, blood pressure, and lipid profiles, except for low-density lipoprotein cholesterol levels

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Constipation: Common when starting GLP-1 medication

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Patients should report severe or persistent abdominal pain, chest pain, palpitations, rapid weight loss, or mood changes to their GP or prescriber urgently

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*Correspondence: Hong-yu Kuang, [email protected] This article was submitted to Integrative and Regenerative Pharmacology, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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