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However, achievements of incretin-based therapies are often tempered by the need to maintain lifestyle changes and by gastrointestinal disturbances that compromise dose escalation, tolerability and adherence, indicating challenges for the design of future agents

From a GRADE perspective, the certainty of evidence was rated as high for efpeglenatides renal composite benefit (large, blinded CVOT with consistent effects)

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software Heidelberg eye explorer software version 6.9a) adhering to the OSCAR-IB quality control criteria and describing findings in accordance with the APOSTEL criteria [20, 21]

Although some studies have shown positive results, others have reported no effects of GLP-1RAs