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Similarly, heart GPx and GSSG levels increased after 5 weeks of high ascorbate supplementation in guinea pigs [148]
(Loprinzi 2020, Lyman 2018)
Metabolomic analysis We used Biocrates AbsoluteIDQ p180 kit to analyze cardiac metabolites from female mice [Young ( n = 7), Old Con ( n = 8), and Old mAb ( n = 7)] with UPLC-MS/MS Xevo TQ, Waters, Pittsburgh, PA, USA) in the Einstein Stable Isotope and Metabolomics Core, according to the manufacturers instructions (BIOCRATES Life Sciences AG, Innsbruck, Austria)
Dosing Schedules and Timing The timing of each injection and the relationship between doses throughout the week can impact both effectiveness and side effect management
Research into peptides that support gut health can identify complementary compounds that may ease the transition
UI and I% were summarized in Table 3
